Location of the toxicology department of the 6th hospital. Information and advisory toxicological center of the fmba of russia

FGBNU "FCTRB-VNIVI" (Kazan) is a major scientific center of the country, a first category institution of the Ministry of Agriculture of Russia. The main activities of the Institute are: assessment of the toxicological, radiation and epizootological situation in the territory of the Russian Federation and participation in the development of projects of federal target and departmental programs in the field of toxicology, radiobiology and infectious pathology of animals; organizing and conducting research work on the development, production and implementation of medicines for veterinary, agrotechnical and medical purposes. The institution was established by order of the Ministry of Agriculture of the USSR in 1960.

FGBNU "FCTRB-VNIVI" (hereinafter - the Center) has implemented and successfully operates a pharmaceutical quality system that meets the requirements of national rules of good manufacturing practice (GMP) in accordance with Order No. 916 of the Ministry of Industry and Trade of Russia.

The Center has licenses to carry out: production of sterile and non-sterile medicinal products for veterinary use, pharmaceutical activities (trade, storage); works using information constituting a state secret; work with microorganisms of 2-4 pathogenicity groups; operation of radiation sources; educational activities in the field of postgraduate education and advanced training of managers and specialists in the profile of the institution. On the basis of the institution, there is a Testing Center for research of agricultural and food products accredited in accordance with GOST ISO / IEC 17025-2009. In the laboratories of the institute, only in recent years, 17 unique medicines, diagnostic kits and biological preparations have been developed and improved for the first time.

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Svetlana Lybina

The main task of the Institute of Toxicology of the FMBA of Russia, which has more than 80 years of history, is research and practical work on medical support for the chemical safety of the population and the environment. The head of the institution Maxim Borisovich Ivanov tells about the specifics of the work of the institution.

— Maksim Borisovich, the institution you head is unique in many ways. Share some of its features.

“More than 80 years of history of the Institute of Toxicology has been marked by the introduction of unique medicines into healthcare practice, medical means of protection against poisonous substances, and, above all, antidotes of organophosphorus poisonous substances. To solve this problem, a lot of work is being done to develop a general theory of toxic action, as well as in the field of applied pharmacology and the synthesis of drugs.

Dealing with the issues of creating means of medical protection and pharmacotherapy, the Institute naturally came to the need to solve the problems of preclinical evaluation of drugs. For this purpose, the Institute has established a certified Testing Center for Preclinical Research of the Federal State Budgetary Institution of Science "Institute of Toxicology of the Federal Medical and Biological Agency", which operates in accordance with the principles of good laboratory practice of the OECD (GLP OECD). There are very few such centers in the Russian Federation, they can be counted on the fingers. Leading specialists of the center have state certificates and international certificates confirming their qualification in the field of preclinical studies according to the GLP system.

In addition, the Institute of Toxicology is the only institution in Russia that has preserved and developed an integrated approach to the training of qualified specialists in various areas of toxicology and pharmacology through postgraduate studies and advanced training as part of additional professional education.

— The Institute is known for its powerful scientific base; at different times, outstanding scientists — toxicologists and pharmacologists — worked in it. What is in the area of ​​scientific interests of the institution today?

— One of the main areas of research activity of the Institute has been and remains the study of the toxicity of the highest priority and dangerous chemical compounds and the toxic processes they cause. This is what creates the fundamental basis for solving all scientific and practical problems to ensure chemical safety.

Another important area is the development and implementation of special medical protective equipment, as well as the search for effective medical technologies and intoxication therapy regimens using existing pharmacological preparations. The creation of original antidotes and poisoning therapy from the idea of ​​chemical synthesis to the development of finished dosage forms is our main research strategy.

In recent years, studies have been developed related to solving the problems of practical health care to ensure the chemical safety of certain contingents of workers in hazardous industries and the population of Russia. This includes substantiating the principles and methods for early diagnosis of the toxic effects of priority environmental pollutants—heavy metals and organic compounds. It was the studies of the toxic effects of these groups of pollutants that became the basis for the scientific substantiation and development of a new organizational form of medical care for the population in diseases of chemical etiology - outpatient toxicology.

Within the framework of the Federal Target Program "National System of Chemical and Biological Safety of the Russian Federation (2009-2014)", work has begun on the creation of centers for the indication and diagnosis of chemical poisoning. The Institute conducts a whole range of research aimed at developing a scientific, methodological and organizational basis for the efficient operation of the centers. Modern chemical-analytical methods and technologies are being developed, work is underway to create state standard samples, as well as the development of measurement methods. Essential for us is the necessary certification of products under development and entry into state registers.

Reference materials developed at the Institute for the composition of biomaterials containing toxic metals are registered as state reference materials, including as interstate ones, are included in the Register of Interstate Reference Materials for the Composition and Properties of Substances and Materials of the States Parties to the “Agreement on the Agreed Policy in the Field of Standardization, metrology and certification.

It is traditional to conduct studies to assess safety and improve pharmacotherapy in the treatment of eye lesions caused by lachrymators and irritants to prevent possible long-term effects of exposure to self-defense gas weapons.

A relatively new line of scientific research at the Institute is the development of a methodology for assessing the genotoxic and cytotoxic effects of priority ecotoxicants using modern criteria-based assessments and methods for detecting violations.

— What research is carried out to ensure chemical safety?

— Within the framework of the mentioned Federal Target Program, extensive work has been done to assess the elemental status of the population of various regions of the Russian Federation, as a result of which five volumes of the manual “Elemental Status of the Population of Russia” and “Atlas. The elemental status of the population of Russia. The materials of these publications can be one of the bases for making managerial decisions to ensure the chemical safety of the population.

The problem of toxicological safety assessment of various environmental objects (water, soil, production and consumption waste) is constantly in the sphere of scientific and practical interests of the institution. In 1995, the Testing Laboratory for Analytical Ecotoxicology was established on the basis of the Institute of Toxicology. Within the scope of accreditation, it carries out the selection and examination of samples of natural and drinking water, wastewater discharged into open water bodies; sampling and examination of soil, soil, bottom sediment samples; atmospheric air, working area air, industrial emissions into the atmosphere; production and consumption waste, as well as the study of physical environmental factors.

— Surely you cooperate with foreign colleagues. How would you define the vector of this interaction: rivalry or cooperation?

— In terms of international scientific and technical cooperation at the Institute in the period from 2009 to 2013, work was carried out on the projects of the International Scientific and Technical Center (ISTC). The Institute worked as a co-executor of the research project "The use of reactive metal nanoparticles in environmental protection: from fundamental knowledge to practical applications" with the financial support of the United States Environmental Protection Agency (USA EPA). The lead organization - the executor of the project - was the Institute of Organic Chemistry. N.D. Zelinskiy RAS. This work can be seen as a mutually beneficial cooperation.

Currently, active work is underway in the field of harmonization of domestic and international standards for studying the general and specific toxicity of pharmaceutical substances, drugs and chemical products.

Representatives of the Institute actively participate in international conferences on quality assurance systems in the field of biomedical research in Europe and the USA, in fact, representing the interests of our country at the level of the international community.

- In order to develop the tasks of reducing the risk of negative effects of chemical exposure on the population, a unique and so far the only outpatient toxicological institution in Russia was created at the Institute of Toxicology - a specialized consultative and diagnostic polyclinic (KDP). What is the mode of operation?

- The KDP is designed to provide medical care to the population in diseases caused by the action of environmental chemicals, primarily with the toxic effect of heavy metals. The work to provide assistance to the population is carried out in the modes of outpatient counseling and toxic-chemical laboratory research, with the appointment of a course of treatment and subsequent dispensary observation. Residents of St. Petersburg and other regions of the Russian Federation are examined.

The KDP is in constant readiness to carry out medical and sanitary measures to eliminate the consequences of emergency situations (chemical accidents and incidents). Polyclinic specialists are involved in the examination of the contingent served by the medical units of the FMBA of Russia in terms of additional laboratory tests and consultations of toxicologists, which allows medical organizations of the FMBA of Russia to expand the possibilities of examination without increasing the laboratory base.

The Institute of Toxicology is a medical scientific institution engaged in fundamental research in the field of toxicology, pharmaceutical chemistry and pharmacology, as well as the creation on this basis of new means and methods for the prevention and treatment of poisoning.

At present, the main task of the Institute of Toxicology is to obtain new scientific knowledge in the field of natural sciences and use them in the interests of public health, ensuring the defense and security of the state, as well as protecting the environment.

Toxicology of xenobiotics remains one of the main directions of scientific research of the Institute.

This traditional direction is associated with the study of the mechanisms of toxic action, the identification of molecular receptor and physiological targets for the action of poisons, as well as the assessment of the severity of intoxication manifestations and the toxicometric parameters of a wide range of chemical compounds.

Another important area is the development and implementation of special means of medical protection and pharmacotherapy of poisoning. The solution to this problem includes two main approaches. The first one is experimental therapy of intoxications using available pharmacological preparations, including the development of schemes and evaluation of the effectiveness of therapy, as well as the creation of combined dosage forms. The second approach is the creation of original antidotes and poisoning therapy, which includes the whole process from the idea of ​​chemical synthesis to the industrial production of a drug.

One of the few centers in Russia for the creation and implementation of effective means of medical protection (antidotes and pathogenetic therapy) against poisoning by highly toxic chemicals based on the study of the laws of chemical and biological interaction and the study of the mechanisms of toxic action.

The employees of the Institute developed 13 preparations. In practical healthcare, such medicines as pirroxan, an alpha-adrenergic blocker, have been used, which received 5 foreign patents (England, USA, France, Germany and Switzerland) and licenses for production in the USA and Spain; butiroxan - a drug for the treatment of alcohol withdrawal syndrome; chlorazil is an anticholinergic agent. For the development of antidotes for highly toxic substances, the employees of the Institute were awarded State Prizes three times (1951, 1967 and 1981).

In recent years, the Institute of Toxicology has developed research related to solving the problems of practical health care to ensure the chemical safety of certain contingents of workers in hazardous industries and the population of Russia. This includes substantiation of the principles and methods for early diagnosis of the toxic effects of heavy metals and organic compounds - environmental pollutants.

The result of the research of the Institute, devoted to the study of the toxic effects of environmental pollutants on various groups of the population, was the scientific substantiation and development of a new organizational form of medical care for the population with chemical pathology - outpatient toxicology. As part of the Institute since 1997, a consultative and diagnostic polyclinic has been operating - the only specialized toxicological outpatient institution in Russia. The staff of the polyclinic is involved in providing medical and scientific advice in areas of environmental risk.

The great contribution of the Institute to the development of domestic toxicology was awarded with government awards. The works of the Institute were awarded with 3 State Prizes, the Prize of the Russian Academy of Medical Sciences, and jubilee scientific medals. 2 employees of the Institute have high titles of "Honored Doctor of the Russian Federation", more than 40 people were awarded orders and medals.

The Institute of Toxicology is included in the list of organizations and institutions that carry out preclinical studies of medicines (Information letter of Roszdravnadzor No. 01I-344/05 of 07/14/2005). Leading specialists have state certificates and international certificates (Helm global group company Ireland and Bioindustry initiative program of State department USA), confirming qualifications in the field of preclinical studies according to the GLP system.

The testing center for preclinical studies of the Institute of Toxicology of the Federal Medical and Biological Agency of Russia complies with the principles of good laboratory practice of the OECD (GLP OECD). Entry in the register of Rosaccreditation No. 2.

A unique cluster for the development and implementation of new technologies for clinical and chemical-analytical diagnostics and treatment of the adverse effects of environmental chemical factors.